Mixed connective tissue diseases and overlap syndromes don’t fit neatly into a single category – and that’s exactly why careful evaluation matters.
Mixed connective tissue diseases combine symptoms of more than one autoimmune condition – often elements of lupus, scleroderma, and inflammatory myositis – frequently alongside a specific antibody called anti-U1-RNP. They reflect the immune system showing up in more than one pattern at the same time.
Overlap syndromes and undifferentiated connective tissue diseases describe related situations where symptoms cross categories, or where the condition hasn’t yet declared itself clearly. These cases benefit from a physician comfortable with complexity and willing to revisit the picture as it evolves.
Patients may experience a mix of symptoms, including:
Raynaud's phenomenon
Joint pain and swelling
Swollen hands or fingers
Muscle weakness or pain
Skin changes
Fatigue and systemic symptoms
These conditions often evolve over time. Symptoms may appear in one order, then shift; antibody patterns help, but a single label may not capture the full picture. Patience and continued reassessment are part of doing this well.
When symptoms cross categories, the story is the most important diagnostic tool. We make time for it.
Comprehensive antibody testing, organ-specific screening, and structured review of prior records to map what's actually present.
Overlap cases don't need to be forced into a single label. We're comfortable working in the gray and tracking how it evolves.
Mixed connective tissue diseases and overlap syndromes often clarify with time. We stay with the case as the picture comes into focus.
A clear evaluation process designed to reduce uncertainty and build a plan that actually fits.
An extended visit dedicated to your full history, prior workup, and the specific mix of symptoms you're experiencing.
Treatment focused on your active symptoms, with clear priorities even when a single overarching label isn't yet possible.
Regular follow-up to track how the picture is evolving and to refine the plan as symptoms clarify or shift.
A complimentary 15-minute consultation is a low-pressure way to see whether working together feels like the right fit. No commitment – just a chance to be heard and explore next steps.
Every patient journey begins with a simple, no-cost conversation. From there, you choose the path that fits where you are right now.
A brief introductory conversation to discuss your concerns and answer questions about this practice. No diagnosis, treatment, or medical advice is provided during this call.
Step 2
A two-visit structured process designed to fully understand your condition and establish a clear path forward.
Ongoing Membership Care
$450/month
Long-term, relationship-based care focused on managing your condition and improving your quality of life.
Our specialty rheumatology practice proudly serves patients throughout the Colorado Front Range.
Serving patients across: Denver, Colorado Springs, Aurora, Fort Collins, Lakewood, Thornton, Arvada, Westminster, Pueblo, Greeley, Boulder, Centennial, Englewood, Littleton, Evergreen, Grand Junction, Aspen, Glenwood Springs.
